van der Velde C D
J Clin Psychiatry. 1981 Apr;42(4):138-41.
The antidepressant effect of maprotiline, a tetracyclic compound, was compared with that of imipramine in a four-week, double-blind, placebo controlled study with neurotic depressives. On all factors of the Hamilton Depression Rating Scale and on most items of the Zung Self-Rating Scales for Depression and Anxiety, maprotiline appeared slightly more effective than imipramine and showed a faster onset of action. In addition, it appeared to cause fewer anticholinergic side effects.
在一项针对神经症性抑郁症患者的为期四周的双盲、安慰剂对照研究中，对四环化合物马普替林的抗抑郁效果与丙咪嗪进行了比较。在汉密尔顿抑郁评定量表的所有因子以及抑郁和焦虑自评量表的大多数项目上，马普替林似乎比丙咪嗪稍有效，且起效更快。此外，它似乎引起的抗胆碱能副作用更少。
