Kittle J D, Calle L M, Sullivan P D
Mutat Res. 1981 Feb;80(2):259-64. doi: 10.1016/0027-5107(81)90098-1.
The effect of phenothiazine and 11 of its derivatives on the mutagenicity of benzo[a]pyrene, as measured by the Ames test was investigated. Significant anti-mutagenic activity was detected for 10 phenothiazine derivatives, with the 2-chloro derivative being the most effective inhibitor tested and promazine the only phenothiazine drug tested which has no demonstrable inhibitory activity. It is considered that the anti-mutagenic activity and therefore potentially anticarcinogenic activity of these derivatives should be of interest to epidemiologists.
通过艾姆斯试验测定了吩噻嗪及其11种衍生物对苯并[a]芘致突变性的影响。检测到10种吩噻嗪衍生物具有显著的抗诱变活性，其中2-氯衍生物是所测试的最有效的抑制剂，而丙嗪是所测试的唯一一种没有明显抑制活性的吩噻嗪药物。据认为，这些衍生物的抗诱变活性以及因此潜在的抗癌活性应该会引起流行病学家的兴趣。
