在沙门氏菌/哺乳动物微粒体诱变性试验中石棉纤维对微粒体酶的苯并(a)芘呈递作用
Presentation of benzo(a)pyrene to microsomal enzymes by asbestos fibers in the Salmonella/mammalian microsome mutagenicity test.
作者信息
Szyba K, Lange A
出版信息
Environ Health Perspect. 1983 Sep;51:337-41. doi: 10.1289/ehp.8351337.
Abstract
The potential effect of asbestos fibers on mutagenicity of benzo(a)pyrene was investigated by using the Ames test. Asbestos fibers without a coating of benzo(a)pyrene or benzo(a)pyrene when not dissolved in DMSO lacked any mutagenic effect in the Salmonella/mammalian microsome mutagenicity test. However, when benzo(a)pyrene was adsorbed onto asbestos, significant numbers of mutated bacteria were observed. This shows that asbestos fibers can serve a carrier role presenting benzo(a)pyrene to the enzymatic microsomal system, thus enhancing mutagenicity of this compound.
摘要
采用艾姆斯试验研究了石棉纤维对苯并(a)芘诱变性的潜在影响。在沙门氏菌/哺乳动物微粒体诱变性试验中，未被苯并(a)芘包覆的石棉纤维或未溶解于二甲基亚砜的苯并(a)芘均无任何诱变作用。然而，当苯并(a)芘吸附在石棉上时，观察到大量突变细菌。这表明石棉纤维可以起到载体作用，将苯并(a)芘呈递给微粒体酶系统，从而增强该化合物的诱变性。
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