Bignami M, Conti G, Crebelli R, Carere A
Mutat Res. 1981 Feb;80(2):265-72. doi: 10.1016/0027-5107(81)90099-3.
7 procarcinogens belonging to different chemical classes (nitrosamines, hydrazoalkanes, oxazaphosphorines and aromatic amines) were tested in A. nidulans for the induction of point mutations with two genetic systems (8-AG resistance and induction of methionine suppressors). Dimethylnitrosamine, diethylnitrosamine, nitrosomorpholine, dimethylhydrazine, procarbazine and cyclophosphamide gave positive results with a good dose--effect relationship in the growth-mediated assay, whereas they gave negative or borderline positive results in the plate incorporation assay. 2-Aminoanthracene was completely negative with both experimental procedures. DMN, DEN and NM were also tested for their ability to induce somatic segregation: all were positive when assayed in the growth-mediated assay.
属于不同化学类别的7种前致癌物（亚硝胺、偶氮烷烃、恶唑磷和芳香胺）在构巢曲霉中进行了测试，采用两种遗传系统（8-氮鸟嘌呤抗性和甲硫氨酸抑制子诱导）来诱导点突变。二甲基亚硝胺、二乙基亚硝胺、亚硝基吗啉、二甲基肼、丙卡巴肼和环磷酰胺在生长介导试验中呈现阳性结果，且具有良好的剂量-效应关系，而在平板掺入试验中则呈现阴性或临界阳性结果。2-氨基蒽在两种实验程序中均完全呈阴性。还测试了二甲基亚硝胺、二乙基亚硝胺和亚硝基吗啉诱导体细胞分离的能力：在生长介导试验中进行测定时，所有结果均为阳性。
