促黄体生成素释放激素类似物对垂体调节和生殖行为影响的分离

Dissociation of effects of LH-RH analogs on pituitary regulation and reproductive behavior.

作者信息

Kastin A J, Coy D H, Schally A V, Zadina J E

出版信息

Pharmacol Biochem Behav. 1980 Dec;13(6):913-4. doi: 10.1016/0091-3057(80)90228-2.

Abstract

Analogs of LH-RH were studied for their effect on lordosis in ovariectomized rats primed with estrogen. Classified by their gonadotropin-releasing activity, representatives of three types of analogs were tested for facilitation of lordotic (L) responses of preselected females to mounting (M) by male studs. Positive responses (L/M greater than 0.5) were found after SC administration of LH-RH peptides modified so as to be inhibitory, stimulatory, or inactive in releasing LH and FSH. The results further support the concept of a dissociation between the endocrine and extra-endocrine effects of peripherally injected hypothalamic peptides.

摘要

研究了促黄体生成素释放激素（LH-RH）类似物对用雌激素预处理的去卵巢大鼠脊柱前凸的影响。根据其促性腺激素释放活性进行分类，测试了三种类型类似物的代表物对预选雌性大鼠对雄性种鼠交配（M）的脊柱前凸（L）反应的促进作用。皮下注射经修饰后在释放促黄体生成素（LH）和促卵泡生成素（FSH）方面具有抑制、刺激或无活性作用的LH-RH肽后，发现了阳性反应（L/M大于0.5）。结果进一步支持了外周注射下丘脑肽的内分泌和内分泌外效应之间存在分离的概念。