Haseltine F P, Ohno S
Science. 1981 Mar 20;211(4488):1272-8. doi: 10.1126/science.7010601.
Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.
性别分化是将遗传性别转化为性腺性别的结果。如果没有可识别的男性化信号，胚胎性腺将进行卵巢分化。性腺分化的主要决定因素似乎是一种称为H-Y抗原的细胞表面抗原的存在与否。H-Y抗原表达的调控很复杂，涉及Y染色体、X染色体以及可能的常染色体上调控位点之间的相互作用。
