Terz J J, King E R, Lawrence W
Surgery. 1981 Apr;89(4):449-53.
Two hundred forty-eight patients with primary epidermoid carcinoma of the oral cavity, oropharynx, and hypopharynx, stages II, III, and IV were entered into a prospective randomized clinical trial of preoperative irradiation therapy (700 rads X 2) and surgery versus surgery alone. At 5 years both groups had a similar survival when analyzed according to stage of disease, primary site, or lymph node status. However, the group of patients receiving preoperative irradiation showed a lower incidence of local recurrence (22% versus 36%) preoperative irradiation showed a lower incidence of local recurrence (22% versus 36%) (P = 0.02). From this study we conclude that preoperative irradiation in this dose schedule has little influence on the ultimate outcome after surgical treatment of head and neck cancer.
248例患有口腔、口咽和下咽原发性表皮样癌的II、III和IV期患者进入了一项前瞻性随机临床试验，该试验比较术前放射治疗（700拉德×2）加手术与单纯手术的效果。在5年时，根据疾病分期、原发部位或淋巴结状态进行分析，两组患者的生存率相似。然而，接受术前放疗的患者组局部复发率较低（22%对36%），术前放疗显示局部复发率较低（22%对36%）（P = 0.02）。从这项研究中我们得出结论，这种剂量方案的术前放疗对头颈癌手术治疗后的最终结果影响很小。
