Orringer E P, Felice A, Reese A, Wilson J B, Lam H, Gravely M E, Huisman T H
Hemoglobin. 1978;2(4):315-32. doi: 10.3109/03630267809005343.
A second instance of the unstable mutant Hb Nottingham (alpha2beta2 (FG5) 98 Val leads to Gly) is reported in a 7-year-old boy. Because of splenomegaly, cholelithiasis, and frequent episodes of abdominal pain, he underwent a splenectomy and cholecystectomy at age 6. The surgery resulted in both an amelioration of his RBC destruction and an acceleration of his rate of growth.
一名7岁男孩被报道出现了不稳定突变型血红蛋白诺丁汉的第二种情况（α2β2 (FG5) 98缬氨酸突变为甘氨酸）。由于脾肿大、胆结石以及频繁的腹痛发作，他在6岁时接受了脾切除术和胆囊切除术。手术既改善了他红细胞的破坏情况，又加快了他的生长速度。
