Lundström M, Eklundh J O
Acta Ophthalmol (Copenh). 1980 Aug;58(4):639-44. doi: 10.1111/j.1755-3768.1980.tb08306.x.
Lack of nerve fibre layer opacity and a granular appearance of the retina are important funduscopic signs in optic atrophy. In this pilot study serially obtained fundus photographs from a case with developing optic atrophy where subjected to computer densitometry. A monotonic increase in local density variations was found during evolution of optic atrophy. The change in density variations closely followed the funduscopic change in nerve fibre layer opacity. This method makes it possible to detect and quantify diffuse atrophy of the retinal nerve fibre layer.
缺乏神经纤维层混浊以及视网膜呈颗粒状外观是视神经萎缩重要的眼底体征。在这项初步研究中，对一名视神经萎缩进展期患者连续拍摄的眼底照片进行了计算机密度测定。结果发现，在视神经萎缩进展过程中局部密度变化呈单调增加。密度变化的改变与神经纤维层混浊的眼底变化密切相关。这种方法能够检测并量化视网膜神经纤维层的弥漫性萎缩。
