Suzuki S, Franco-Saenz R, Tan S Y, Mulrow P J
Am J Physiol. 1981 Mar;240(3):E286-9. doi: 10.1152/ajpendo.1981.240.3.E286.
The role of prostaglandins in the control of renin release in vivo was evaluated in the conscious rat. Indomethacin suppressed urinary prostaglandin E2 (PGE2) excretion from 5.3 +/- 0.5 to 2.6 +/- 0.5 ng/3 h (P less than 0.001). Basal plasma renin activity (PRA) fell from 6.20 +/- 1.07 to 2.98 +/- 0.45 ng . ml-1 . h-1 (P less than 0.02). Indomethacin suppressed PRA stimulated by furosemide, insulin-induced hypoglycemia, hydralazine, isoproterenol, arachidonic acid, and sodium-free diet, whereas PRA stimulated by PGE2 was not suppressed by indomethacin. The suppression of PRA by indomethacin in the sodium-deplete state rules out sodium retention as the mechanism of action of indomethacin. These results indicate that inhibition of prostaglandin synthesis by indomethacin partially blocks the renin response to several of the known stimulators, suggesting that prostaglandins may play a pivotal role in the control of renin release.
在清醒大鼠体内评估前列腺素在肾素释放调控中的作用。吲哚美辛使尿前列腺素E2（PGE2）排泄量从5.3±0.5降至2.6±0.5 ng/3 h（P<0.001）。基础血浆肾素活性（PRA）从6.20±1.07降至2.98±0.45 ng·ml-1·h-1（P<0.02）。吲哚美辛抑制速尿、胰岛素诱导的低血糖、肼屈嗪、异丙肾上腺素、花生四烯酸和无钠饮食刺激引起的PRA，而PGE2刺激引起的PRA不受吲哚美辛抑制。在钠缺乏状态下吲哚美辛对PRA的抑制排除了钠潴留作为吲哚美辛作用机制的可能性。这些结果表明，吲哚美辛对前列腺素合成的抑制部分阻断了肾素对几种已知刺激物的反应，提示前列腺素可能在肾素释放的调控中起关键作用。
