Wender P H, Reimherr F W, Wood D R
Arch Gen Psychiatry. 1981 Apr;38(4):449-56. doi: 10.1001/archpsyc.1981.01780290083009.
This study replicated an earlier one dealing with the diagnosis and treatment of attention deficit disorder (ADD, or minimal brain dysfunction) in adults. Subjects who met provisional operational criteria for adult ADD were entered in a random-assignment, parallel, double-blind trial of placebo and pemoline, a noneuphorigenic psychostimulant drug effective in children with ADD. There was improvement in both the pemoline group and the placebo group, but the difference in improvement was not statistically significant. When the analyses were confined to that subgroup of patients whose parents had described them in the 95th percentile of childhood "hyperactivity" or when the hyperactivity score was partialled out statistically, pemoline was demonstrably more effective than placebo. Revised operational criteria for adult ADD are proposed.
本研究重复了一项早期研究，该研究涉及成人注意力缺陷障碍（ADD，或轻度脑功能障碍）的诊断和治疗。符合成人ADD临时操作标准的受试者被纳入一项安慰剂和匹莫林的随机分组、平行、双盲试验，匹莫林是一种对患有ADD的儿童有效的非致欣快性精神兴奋剂药物。匹莫林组和安慰剂组均有改善，但改善程度的差异无统计学意义。当分析仅限于其父母将他们描述为处于童年“多动”第95百分位的患者亚组时，或者当多动评分通过统计学方法排除时，匹莫林明显比安慰剂更有效。提出了成人ADD的修订操作标准。
