Neale S, Solt A K
Chem Biol Interact. 1981 May;35(2):199-205. doi: 10.1016/0009-2797(81)90143-5.
Ascorbic acid was tested for its ability to increase or decrease the induction of bacterial mutations by dimethylnitrosamine (DMN) or aminopyrine plus nitrite within intact mice. No evidence was found of the mutagenicity of ascorbic acid itself when tested alone or in the presence of copper ions. Similarly, no increase or decrease in the DMN-induced mutation frequency was observed. However, ascorbic acid was found to decrease the aminopyrine/nitrite-induced mutation frequency to an extent which was dependent on the experimental conditions used.
在完整小鼠体内，测试了抗坏血酸增加或降低二甲基亚硝胺（DMN）或氨基比林加亚硝酸盐诱导细菌突变的能力。单独测试或在铜离子存在下测试时，未发现抗坏血酸本身具有致突变性的证据。同样，未观察到DMN诱导的突变频率增加或降低。然而，发现抗坏血酸可将氨基比林/亚硝酸盐诱导的突变频率降低，降低程度取决于所使用的实验条件。
