Couch D B, Friedman M A
Mutat Res. 1976 Apr;38(2):89-96. doi: 10.1016/0165-1161(76)90002-9.
Nitrososarcosine, not mutagenic itself in the host-mediated assay using Salmonella typhimurium G46 as indicator organism, lowered the mutant frequency produced by dimethylnitrosamine (DMN). Mutant frequency was significantly depressed when 1.0 g/kg nitrososarcosine was administered by gavage 0.5--2.0 h prior to intramuscular injection of 500 mg/kg DMN. Doses of nitrososarcosine as low as 37.2 mg/kg administered 45 min prior to dimethylnitrosamine treatment produced statistically significant reduction of mutant frequency. Dimethylnitrosamine, diethylnitrosamine and dibutylnitrosamine (500 mg/kg) also partially suppressed the mutant frequency produced by 500 mg/kg DMN when administered 45 min prior to dmn. diethylnitrosamine and dibutylnitrosamine were not found to be mutagenic in this test system.
亚硝基肌氨酸本身在以鼠伤寒沙门氏菌G46作为指示生物的宿主介导试验中不具有致突变性，但它能降低二甲基亚硝胺（DMN）产生的突变频率。当在肌肉注射500mg/kg DMN前0.5 - 2.0小时通过灌胃给予1.0g/kg亚硝基肌氨酸时，突变频率显著降低。在二甲基亚硝胺处理前45分钟给予低至37.2mg/kg的亚硝基肌氨酸剂量，可使突变频率产生统计学上的显著降低。当在二甲基亚硝胺处理前45分钟给予时，二甲基亚硝胺、二乙基亚硝胺和二丁基亚硝胺（500mg/kg）也部分抑制了500mg/kg DMN产生的突变频率。在该测试系统中未发现二乙基亚硝胺和二丁基亚硝胺具有致突变性。
