Dawnay A B, Cattell W R
Clin Nephrol. 1981 Jan;15(1):5-8.
Serum Tamm-Horsfall glycoprotein (THG) concentrations were measured by radioimmunoassay in a group of 95 people with normal renal function and lay in the range of 70 to 540 ng/ml. None was detectable in 6 anephric patients. Patients on hemodialysis but with both kidneys in situ had concentrations below the lower limit of normal, and in some cases THG was undetectable. Healthy kidney donors generally showed a decrease in serum levels following uninephrectomy although these remained within the normal range. In contrast, all transplant recipients showed a marked increase in serum THG concentration, the rates of rise being apparently dependent upon initial graft function. These findings support the view that THG is a normal constituent of human serum whose levels are related to the amount of renal functioning mass.
采用放射免疫分析法测定了95例肾功能正常者的血清Tamm-Horsfall糖蛋白（THG）浓度，范围在70至540 ng/ml之间。6例无肾患者中未检测到THG。接受血液透析但双肾原位的患者其THG浓度低于正常下限，部分患者检测不到THG。健康肾供者在单侧肾切除术后血清水平通常会下降，不过仍在正常范围内。相比之下，所有肾移植受者血清THG浓度均显著升高，升高速率显然取决于初始移植肾功能。这些发现支持以下观点：THG是人体血清的正常成分，其水平与有功能的肾组织量相关。
