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[血清和尿中Tamm-Horsfall蛋白在肾移植监测中的作用]

[Role of serum and urinary Tamm-Horsfall protein in the surveillance of kidney transplants].

作者信息

Hartmann L, Bringuier A F, Chopin N, Kechrid C, Fries D

出版信息

C R Seances Soc Biol Fil. 1985;179(4):452-61.

PMID:2938674
Abstract

The study of 24-h urinary excretion proves to be quite interesting from a theoretical point of view on account of its topographic origin in the nephron and from a practical point of view to control renal transplant patients with favourable or unfavourable course. In both cases, the results we obtain are in accordance with that of blood creatinine assay and ratio N-acetyl-beta-D-glucosaminidase (NAG)/creatinine in urine. The prolonged study of serum THG concentration confirms the previous data regarding the outcome of renal grafts. Moreover, particularly low concentration rates probably imply the interference of factors such as: renal toxins or anti-THG autoantibodies.

摘要

从理论角度来看,鉴于其在肾单位中的地形学起源,以及从实际角度来看,为了控制肾移植患者的病情走向(无论病情有利或不利),对24小时尿排泄的研究都颇具趣味。在这两种情况下,我们获得的结果都与血肌酐测定结果以及尿液中N - 乙酰 - β - D - 氨基葡萄糖苷酶(NAG)/肌酐比值相符。对血清THG浓度的长期研究证实了先前关于肾移植结果的数据。此外,特别低的浓度率可能意味着存在诸如肾毒素或抗THG自身抗体等因素的干扰。

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1
[Role of serum and urinary Tamm-Horsfall protein in the surveillance of kidney transplants].[血清和尿中Tamm-Horsfall蛋白在肾移植监测中的作用]
C R Seances Soc Biol Fil. 1985;179(4):452-61.
2
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Urinary N-acetyl-beta-D-glucosaminidase and neopterin aid in the diagnosis of rejection and acute tubular necrosis in initially nonfunctioning kidney grafts.尿N-乙酰-β-D-氨基葡萄糖苷酶和新蝶呤有助于诊断初始无功能肾移植中的排斥反应和急性肾小管坏死。
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引用本文的文献

1
Urinary Tamm-Horsfall protein as a marker of renal transplant function.尿Tamm-Horsfall蛋白作为肾移植功能的标志物。
Urol Res. 1994;22(3):131-6. doi: 10.1007/BF00571838.