Rao G S
Mol Cell Endocrinol. 1981 Feb;21(2):97-108. doi: 10.1016/0303-7207(81)90047-2.
Characteristics of the processes by which steroid and thyroid hormones enter tissues, cells and membrane vesicles are reviewed. Several authors suggest that entry is by passive diffusion: the accumulation within cells is attributed to cytoplasmic binding proteins. Other authors, however, propose a membrane-mediated process of entry. The involvement of saturability, high specificity, sensitivity to temperature, sulfhydryl and cell-surface-perturbing reagents and hydrolytic enzymes support the latter view. Purified plasma-membrane vesicle preparations retain several characteristics of entry shown by intact cells. Intracellular hormone-binding protein would not contribute to processes observed with these preparations.
本文综述了类固醇激素和甲状腺激素进入组织、细胞和膜泡的过程的特征。几位作者认为，进入是通过被动扩散：细胞内的积累归因于细胞质结合蛋白。然而，其他作者提出了一种膜介导的进入过程。可饱和性、高特异性、对温度、巯基和细胞表面干扰试剂以及水解酶的敏感性支持了后一种观点。纯化的质膜泡制剂保留了完整细胞所显示的几种进入特征。细胞内激素结合蛋白不会对这些制剂所观察到的过程产生影响。
