Shah D K, Verma S C
Indian J Physiol Pharmacol. 1980 Oct-Dec;24(4):346-50.
Insulin (5 to 40 I.U.) produced dose-dependent positive inotropic effect in the isolated rat heart. The responses to insulin were markedly inhibited in the presence of propranolol (1 . 1X10(-6) M). Insulin responses were markedly reduced in reserpine pretreated (5 mg/kg, i.p.) rats. Theophylline (4.4 mM), the phosphodiesterase inhibitor, potentiated the responses to insulin, whereas imidazole (20 mM), the phosphodiesterase stimulator inhibited the responses to insulin. The data suggest that the positive inotropic effects of insulin in rat heart is mediated through the release of cardiac catecholamines which stimulates beta-adrenoceptors. The final mediator of cardiac action seems to be cyclic-AMP.
胰岛素（5至40国际单位）对离体大鼠心脏产生剂量依赖性正性肌力作用。在普萘洛尔（1.1×10⁻⁶ M）存在的情况下，对胰岛素的反应明显受到抑制。在利血平预处理（5毫克/千克，腹腔注射）的大鼠中，胰岛素反应明显降低。磷酸二酯酶抑制剂茶碱（4.4毫摩尔）增强了对胰岛素的反应，而磷酸二酯酶刺激剂咪唑（20毫摩尔）则抑制了对胰岛素的反应。数据表明，胰岛素在大鼠心脏中的正性肌力作用是通过释放刺激β-肾上腺素能受体的心脏儿茶酚胺介导的。心脏作用的最终介质似乎是环磷酸腺苷。
