Beacham B E, Greer K E, Andrews B S, Cooper P H
J Am Acad Dermatol. 1980 Nov;3(5):506-10. doi: 10.1016/s0190-9622(80)80117-4.
The variety of cutaneous lesions in primary systemic or multiple myeloma-associated amyloidosis is impressive and includes purpura, waxy papules, tumors, plaques, alopecia, and, rarely, bullae. We report a patient in whom the diagnoses of amyloidosis and multiple myeloma were established after he presented with bullae and extensive infiltrated, purpuric plaques. Immunoelectrophoresis of the blister fluid revealed an IgA kappa monoclonal protein similar to that found in the patient's serum and urine.
原发性系统性或多发性骨髓瘤相关淀粉样变性的皮肤病变种类繁多，令人印象深刻，包括紫癜、蜡样丘疹、肿瘤、斑块、脱发，以及罕见的大疱。我们报告了一名患者，他出现大疱和广泛浸润性紫癜性斑块后被确诊为淀粉样变性和多发性骨髓瘤。水疱液的免疫电泳显示出一种IgA κ单克隆蛋白，与在患者血清和尿液中发现的蛋白相似。
