Fujita Yasuyuki, Tsuji-Abe Yukiko, Sato-Matsumura Kazuko C, Akiyama Masashi, Shimizu Hiroshi
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
J Am Acad Dermatol. 2006 Apr;54(4):712-4. doi: 10.1016/j.jaad.2005.12.031.
We report the case of a 61-year-old Japanese man with IgG lambda-type multiple myeloma, who presented with nail dystrophy as the initial manifestation of systemic amyloidosis. Subsequently he developed bullous amyloidosis. This report documents these two rare signs of systemic amyloidosis and demonstrates the precise location of cutaneous blister formation and amyloid deposition by fluorescence antigen mapping and electron microscopy.
我们报告了一例61岁的日本男性IgG λ型多发性骨髓瘤患者，其以甲营养不良作为系统性淀粉样变性的初始表现。随后他发展为大疱性淀粉样变性。本报告记录了系统性淀粉样变性的这两种罕见体征，并通过荧光抗原定位和电子显微镜显示了皮肤水疱形成和淀粉样蛋白沉积的确切位置。
