Nobre G, Sobral T, Ferreira A F
Mycopathologia. 1981 Jan 30;73(1):39-41. doi: 10.1007/BF00443012.
The sensitivity to nystatin, 5-fluorocytosine (5-FC) or both was studied for 131 clinical isolates of Candida albicans, 47 of Candida parapsilosis, 34 of Candida tropicalis, 7 of Candida guilliermondii, 28 of Torulopsis glabrata and 1 of Torulopsis candida. All strains were inhibited by concentrations of nystatin within the usual range of sensitivity except one strain of T. glabrata and another of T. candida whose minima inhibitory concentrations (MICs) were respectively 250 U/ml and greater than 20000 U/ml. In respect to 5-FC it was found, after 7 days of incubation at 37 degrees C, the following frequencies of resistance: C. albicans 28/106 (26%), C. parapsilosis 11/47 (23%), C. tropicalis 24/34 (71%), C. guilliermondii 1/7, T. glabrata 1/28 (4%) and T. candida 0/1. It was particularly striking the activity of 5-FC against T. glabrata.
对131株白色念珠菌、47株近平滑念珠菌、34株热带念珠菌、7株季也蒙念珠菌、28株光滑球拟酵母菌和1株假丝球拟酵母菌的临床分离株进行了对制霉菌素、5-氟胞嘧啶（5-FC）或两者的敏感性研究。除1株光滑球拟酵母菌和1株假丝球拟酵母菌外，所有菌株均被制霉菌素浓度抑制在通常的敏感范围内，这两株菌的最小抑菌浓度（MIC）分别为250 U/ml和大于20000 U/ml。关于5-FC，在37℃孵育7天后发现以下耐药频率：白色念珠菌28/106（26%），近平滑念珠菌11/47（23%），热带念珠菌24/34（71%），季也蒙念珠菌1/7，光滑球拟酵母菌1/28（4%），假丝球拟酵母菌0/1。5-FC对光滑球拟酵母菌的活性尤为显著。
