一项比较舒林酸与吲哚美辛治疗类风湿性关节炎的双盲研究。
A double-blind study comparing sulindac with indomethacin in rheumatoid arthritis.
作者信息
Lund H I, Donde R, Petersen P H
出版信息
Scand J Rheumatol Suppl. 1980;37:1-6. doi: 10.3109/03009748109095327.
Forty-two patients with definite or classical rheumatoid arthritis were included in a 6-week double-blind study to compare sulindac with indomethacin. Patients were randomly assigned to therapy, either sulindac 100 mg b.i.d. (plus indomethacin placebo) or indomethacin 25 mg t.i.d. (plus sulindac placebo). As required dosage was increased to either sulindac 200 mg b.i.d. or indomethacin 50 mg t.i.d. Efficacy of the two drugs was found to be equal but sulindac was better tolerated than indomethacin.
42例确诊或典型类风湿性关节炎患者被纳入一项为期6周的双盲研究，以比较舒林酸与吲哚美辛。患者被随机分配接受治疗，要么是舒林酸100毫克，每日两次（加吲哚美辛安慰剂），要么是吲哚美辛25毫克，每日三次（加舒林酸安慰剂）。根据需要，剂量可增加到舒林酸200毫克，每日两次或吲哚美辛50毫克，每日三次。结果发现两种药物疗效相当，但舒林酸的耐受性优于吲哚美辛。
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