Fischer U, Bruns W, Jutzi E, Ratzmann K P, Abel P, Bombor H, Salzsieder E, Freyse E J
Z Gesamte Inn Med. 1981 Jan 1;36(1):19-26.
Long-term hyperglycaemia in diabetics favours the development of diabetic microangiopathy. The clinical research, therefore, aims to find new opportunities to obtain normoglycaemia in insulin-dependent diabetics mainly by following three patts: -transplantation of pancreatic tissue or isolated islets of Langerhans - implantation of so-called hybrid pancreas and -construction of an artificial B-cell. This paper gives a review of the development, principle of function and clinical application of the glucose controlled insulin infusion system (closed loop system) and of the so-called open loop system without feedback to the glucose values. Results of our own investigations with GCIIS "Biostator", the development of an algorithm of our for the correlation between glucose and insulin behaviour and the first results with the insulin therapy with micropumps (open loop system) were demonstrated and discussed critically.
糖尿病患者的长期高血糖状态有利于糖尿病微血管病变的发展。因此，临床研究主要通过以下三个途径致力于为胰岛素依赖型糖尿病患者寻找实现血糖正常的新机会：- 胰腺组织或分离的胰岛移植 - 所谓混合胰腺的植入 - 人工B细胞的构建。本文综述了葡萄糖控制胰岛素输注系统（闭环系统）以及所谓无血糖值反馈的开环系统的发展、功能原理和临床应用。展示并批判性地讨论了我们使用GCIIS“生物调节器”进行的自身研究结果、我们开发的葡萄糖与胰岛素行为相关性算法以及微型泵胰岛素治疗（开环系统）的初步结果。
