Carlsson C A, Grevsten S, Pellettieri L
Acta Chir Scand. 1980;146(7):449-57.
This report aims at discussing some of the sources of error and pitfalls involved in evaluating the efficiency of alternative modes of therapy in clinical materials. One of the main obstacles in such analysis is that the therapeutic groups are basically different due to the original selection of patients. In a previous paper (Pellettieri, 1980) a special method was worked out to circumvent this problem. The method requires that the variables of main prognostic importance can be identified. Patients in the different therapeutic groups who have identical patterns of combination of variables (risk profiles) can then be compared and the efficiency of different treatment programs can be evaluated. We believe that this method can be used in other fields of medicine.
本报告旨在探讨在评估临床资料中替代治疗模式的效率时所涉及的一些误差来源和陷阱。此类分析的主要障碍之一是，由于患者的初始选择，治疗组本质上存在差异。在之前的一篇论文（佩莱蒂耶里，1980年）中，研究出了一种特殊方法来规避这个问题。该方法要求能够识别出具有主要预后重要性的变量。然后可以对不同治疗组中具有相同变量组合模式（风险概况）的患者进行比较，并评估不同治疗方案的效率。我们认为这种方法可应用于医学的其他领域。
