糖尿病中的血清脂蛋白：α-脂蛋白水平与治疗的关系。

Serum lipoproteins in diabetes: relation of alpha-lipoprotein level to therapy.

作者信息

Sommariva D, Scotti L, Massaroli C, Zanaboni L, Bonfiglioli D, Negrati M, Micossi P, Raggi U, Fasoli A

出版信息

Acta Diabetol Lat. 1980 Jul-Dec;17(3-4):237-45. doi: 10.1007/BF02581324.

Abstract

Three hundred and sixty diabetic patients (125 on insulin, 109 on sulfonylureas and 126 on diet alone) were selected to investigate the effect of the type of treatment and of the degree of metabolic control on serum lipoproteins. Prebeta-lipoprotein concentration was higher than normal in all treatment groups. Beta-lipoproteins were significantly higher in diabetic women than in controls. No difference in beta- and prebeta-lipoprotein concentration existed between the 3 treatment groups. Alpha-lipoproteins were significantly higher in insulin-treated than in diet-treated patients irrespective of the degree of metabolic control. The daily dose of insulin and, in patients on diet or sulfonylureas, serum IRI were positively correlated to alpha-lipoprotein concentration while this lipoprotein fraction was not significantly correlated to fasting blood sugar. Alpha-lipoprotein concentration, then, appears to be markedly influenced by exogenous and endogenous insulin, independently of the degree of metabolic control.

摘要

选取360名糖尿病患者（125名使用胰岛素治疗，109名使用磺脲类药物治疗，126名仅采用饮食治疗），以研究治疗方式及代谢控制程度对血清脂蛋白的影响。所有治疗组的前β脂蛋白浓度均高于正常水平。糖尿病女性的β脂蛋白水平显著高于对照组。三个治疗组之间的β脂蛋白和前β脂蛋白浓度无差异。无论代谢控制程度如何，胰岛素治疗患者的α脂蛋白水平显著高于饮食治疗患者。胰岛素每日剂量以及饮食或磺脲类药物治疗患者的血清IRI与α脂蛋白浓度呈正相关，而该脂蛋白组分与空腹血糖无显著相关性。因此，α脂蛋白浓度似乎明显受外源性和内源性胰岛素影响，与代谢控制程度无关。