Bonfiglioli D, Sommariva D, Zanaboni L, Scarpellini P, Bott A, Raggi U, Fasoli A
Eur J Clin Pharmacol. 1981;20(4):263-7. doi: 10.1007/BF00618776.
Indomethacin 50 mg i.v. or p.o. and diclofenac sodium 50 mg p.o. produced a prompt and significant increase in plasma free fatty acid concentration. In 10 subjects who took indomethacin 150 mg/d p.o. for 3 days, plasma post-heparin lipoprotein lipase activity was also significantly increased. The same effect occurred in 9 subjects treated for 3 days with diclofenac sodium 50 mg t.d.s. Since both indomethacin and diclofenac sodium are potent inhibitors of prostaglandin synthetase, these findings are consistent with the hypothesis tht prostaglandins are involved in the feed-back regulation of lipolysis, and mediate the inhibitory effect of lipolysis on lipoprotein lipase activity.
静脉注射或口服50毫克吲哚美辛以及口服50毫克双氯芬酸钠可使血浆游离脂肪酸浓度迅速显著升高。在10名口服吲哚美辛150毫克/天，持续3天的受试者中，血浆肝素后脂蛋白脂肪酶活性也显著升高。9名接受双氯芬酸钠50毫克每日3次治疗3天的受试者也出现了同样的效果。由于吲哚美辛和双氯芬酸钠都是前列腺素合成酶的强效抑制剂，这些发现与前列腺素参与脂解的反馈调节并介导脂解对脂蛋白脂肪酶活性的抑制作用这一假设一致。
