Daubresse J C, Bailly A, Lemy C, Meunier J C, Luyckx A S, Lefebvre P J
Acta Diabetol Lat. 1980 Jul-Dec;17(3-4):247-54. doi: 10.1007/BF02581325.
We have measured fasting C-peptide reactivity (CPR) as well as CPR responses to a test meal in 83 diabetic patients and 41 non diabetic controls. In comparison to controls, basal CPR was decreased in lean insulin-treated diabetics with stable or brittle diabetes and in obese patients with brittle diabetes. Lean and obese maturity-onset diabetics had increased CPR levels and so had obese insulin-treated patients. Nevertheless, the CPR response to the test meal was clearly inadequate in all diabetics. In control patients, there was a positive correlation between fasting blood glucose and CPR levels. On the contrary, lean diabetics demonstrated a negative correlation between these parameters. Hemoglobin A1 levels were negatively correlated to fasting CPR levels in lean diabetics, indicating the importance of residual B-cell function for diabetes control. These correlations were obscured in obese diabetics. In our patients, circulating insulin antibodies had apparently no deleterious effect on metabolic control.
我们测定了83例糖尿病患者和41例非糖尿病对照者的空腹C肽反应性（CPR）以及对试餐的CPR反应。与对照组相比，在胰岛素治疗的瘦型稳定或脆性糖尿病患者以及肥胖脆性糖尿病患者中，基础CPR降低。瘦型和肥胖型成年发病糖尿病患者的CPR水平升高，肥胖胰岛素治疗患者也是如此。然而，所有糖尿病患者对试餐的CPR反应明显不足。在对照患者中，空腹血糖与CPR水平呈正相关。相反，瘦型糖尿病患者这些参数之间呈负相关。在瘦型糖尿病患者中，糖化血红蛋白A1水平与空腹CPR水平呈负相关，表明残余B细胞功能对糖尿病控制的重要性。这些相关性在肥胖糖尿病患者中不明显。在我们的患者中，循环胰岛素抗体显然对代谢控制没有有害影响。
