Madsbad S, Krarup T, Reguer L, Faber O K, Binder C
Diabetologia. 1981 May;20(5):530-4. doi: 10.1007/BF00252760.
In 14 insulin dependent diabetics past their initial remission period B-cell function was evaluated using a test meal before and after 1 week of strict blood glucose control, and again 3 weeks later when the patients were outpatients on conventional therapy. Eight patients with fasting C-peptide above 0.07 nmol/l improved their B-cell function significantly (p Less Than 0.05) during the period of strict blood glucose control. However, the improvement was of short duration and was absent 3 weeks later in most patients. Six patients with fasting C-peptide below or equal to 0.07 nmol/l had no significant improvement in B-cell function during the period of strict control. The study shows that B-cell function and degree of blood glucose control are related in patients with fasting C-peptide above 0.07 nmol/l, and that B-cell function can change within days.
对14名已过初始缓解期的胰岛素依赖型糖尿病患者，在严格血糖控制1周前后通过试餐评估B细胞功能，3周后患者接受常规门诊治疗时再次评估。8名空腹C肽高于0.07 nmol/l的患者在严格血糖控制期间B细胞功能显著改善（p小于0.05）。然而，这种改善持续时间较短，3周后大多数患者的改善情况消失。6名空腹C肽低于或等于0.07 nmol/l的患者在严格控制期间B细胞功能无显著改善。该研究表明，空腹C肽高于0.07 nmol/l的患者中B细胞功能与血糖控制程度相关，且B细胞功能可在数天内发生变化。
