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In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies.

作者信息

Bansal R, Ahmad N, Kidwai J R

出版信息

Acta Diabetol Lat. 1980 Jul-Dec;17(3-4):255-66. doi: 10.1007/BF02581326.

DOI:10.1007/BF02581326
PMID:7013400
Abstract

Purified bovine cathepsin B, when incubated with isolated rat islets of Langerhans, completely converts proinsulin to insulin as demonstrated by the incorporation of 14C-leucine into islet proteins, releasing lysine as the only basic amino acid. Cathepsin B antibodies raised in rabbit inhibited the above conversion.

摘要

相似文献

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本文引用的文献

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THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN.用血红蛋白对胃蛋白酶、胰蛋白酶、木瓜蛋白酶和组织蛋白酶的测定
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Life Sci (1962). 1965 Mar;4:657-63. doi: 10.1016/0024-3205(65)90004-4.
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Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
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Conformational studies of cathepsin B: interaction with specific antibodies.
Indian J Biochem Biophys. 1981 Apr;18(2):110-3.
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Digestive activity of lysosomes. I. The digestion of proteins by extracts of rat liver lysosomes.溶酶体的消化活性。I. 大鼠肝脏溶酶体提取物对蛋白质的消化作用。
J Biol Chem. 1968 Jun 25;243(12):3255-63.
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Method for the isolation of intact islets of Langerhans from the rat pancreas.从大鼠胰腺中分离完整胰岛的方法。
Diabetes. 1967 Jan;16(1):35-9. doi: 10.2337/diab.16.1.35.
8
Cathepsins D, A and B, and the effect of pH in the pathway of protein hydrolysis.
Biochim Biophys Acta. 1971 Jul 25;243(1):137-46. doi: 10.1016/0005-2795(71)90047-x.
9
Studies on the conversion of proinsulin to insulin. I. Conversion in vitro with trypsin and carboxypeptidase B.胰岛素原向胰岛素转化的研究。I. 用胰蛋白酶和羧肽酶B进行体外转化
J Biol Chem. 1971 Nov 25;246(22):6786-91.
10
The nature of the collagenolytic cathepsin of rat liver and its distribution in other rat tissues.大鼠肝脏胶原分解组织蛋白酶的性质及其在大鼠其他组织中的分布。
Biochem J. 1972 May;127(4):685-92. doi: 10.1042/bj1270685.