de Boer A C, Mulder H, Fischer H R, Schopman W, Hackeng W H, Silberbusch J
Acta Med Scand. 1981;209(3):193-8. doi: 10.1111/j.0954-6820.1981.tb11575.x.
In order to further investigate hormonal changes and possible metabolic consequences in acute pancreatitis, 10 cases with a mild form of the disease was studied. The influence of tissue injury per se on the hormones in question was assessed from comparison with the hormone levels in the course of myocardial infarction (MI) in 9 cases. Insulin and glucose showed no consistent changes. Glucagon was suppressed on admission, 22 +/- 10 pg . ml-1, compared with the ultimate concentration, 40 +/- 20 pg . ml-1 (p less than 0.05), and with the initial value in MI, 74 +/- 32 pg . ml-1 (p less than 0.01). Serum calcitonin (CT) was strongly elevated initially, 348 +/- 313 pg . ml-1, compared with the ultimate level, 24 +/- 7 pg . ml-1 (p less than 0.001), and with the normal initial level in MI, 43 +/- 44 pg . ml-1 (p less than 0.01). Serum CT elevations were time-related to a slight reduction in corrected serum Ca, which might reflect a biological expression of this substance. In pancreatitis, parathyroid hormone (PTH) remained normal and unchanged throughout the study, whereas patients with MI had an increased level of this hormone on admission, 0.19 +/- 0.08 microgramEq . 1(-1), compared with the ultimate concentration, 0.09 +/- 0.03 microgram/q . 1(-1) (p less than 0.02) and with the initial concentration in pancreatitis, 0.11 +/- 0.06 microgramEq . 1(-1) (p less than 0.05). Supranormal PTH levels were found in more than half of the infarction patients on days 0 and 1.
为了进一步研究急性胰腺炎时的激素变化及其可能的代谢后果，对10例轻症患者进行了研究。通过与9例心肌梗死（MI）患者病程中的激素水平作比较，评估了组织损伤本身对相关激素的影响。胰岛素和葡萄糖未见一致变化。入院时胰高血糖素受到抑制，为22±10 pg·ml⁻¹，而最终浓度为40±20 pg·ml⁻¹（p＜0.05），与MI患者的初始值74±32 pg·ml⁻¹相比（p＜0.01）。血清降钙素（CT）最初显著升高，为348±313 pg·ml⁻¹，与最终水平24±7 pg·ml⁻¹相比（p＜0.001），与MI患者的正常初始水平43±44 pg·ml⁻¹相比（p＜0.01）。血清CT升高与校正血清钙的轻微降低在时间上相关，这可能反映了该物质的生物学作用。在胰腺炎患者中，甲状旁腺激素（PTH）在整个研究过程中保持正常且无变化，而MI患者入院时该激素水平升高，为0.19±0.08微当量·L⁻¹，与最终浓度0.09±0.03微当量·L⁻¹相比（p＜0.02），与胰腺炎患者的初始浓度0.11±0.06微当量·L⁻¹相比（p＜0.05）。超过半数的梗死患者在第0天和第1天PTH水平高于正常。
