Zamboni G, Albertini A, Zoppi G, Cecchettin M
Eur J Pediatr. 1980 Dec;135(2):195-8. doi: 10.1007/BF00441641.
Blood glucose, insulin, calcium (Ca), phosphorus (P), parathyroid hormone (PTH) and calcitonin (CT) were evaluated in 8 normal children, aged 17-41 months, during an oral glucose load; in 7 normal children, aged 15-42 months, during i.v. glucose infusion; and in 6 normal children, aged 19-40 months, during glucagon administration. During the oral glucose tolerance tests the mean maximum decline of Ca (8.63%) and p (12.66%) was at 120 min, while PTH and CT significantly increased from basal values of 1.36 ng/ml +/- 0.21 and 97 pg/ml +/- 14 to 2.20 ng/ml +/- 0.22 and 140 pg/ml +/- 13, respectively, at 45 min. During i.v. glucagon administration the mean maximum decline of Ca (9.64%) and P (12.28%) was at 30 min. PTH levels rose significantly from basal values of 1.2 mg/ml +/- 0.22 to 2.1 ng/ml +/- 0.32 at 45 min, while CT increased rapidly from basal levels of 90 pg/ml +/- 14 to 127 pg/ml at 15 min. In conclusion, increases in glucose and insulin due to ingestion or infusion of glucose, or to glucagon injection, are therefore not only associated with a fall in serum Ca and P but also with rises in PTH and CT.
对8名年龄在17至41个月的正常儿童进行口服葡萄糖负荷试验，评估其血糖、胰岛素、钙（Ca）、磷（P）、甲状旁腺激素（PTH）和降钙素（CT）水平；对7名年龄在15至42个月的正常儿童进行静脉输注葡萄糖试验，评估上述指标；对6名年龄在19至40个月的正常儿童进行胰高血糖素给药试验，评估上述指标。在口服葡萄糖耐量试验期间，钙（平均最大降幅8.63%）和磷（平均最大降幅12.66%）的最大降幅出现在120分钟时，而甲状旁腺激素和降钙素在45分钟时分别从基础值1.36 ng/ml±0.21和97 pg/ml±14显著升至2.20 ng/ml±0.22和140 pg/ml±13。在静脉注射胰高血糖素期间，钙（平均最大降幅9.64%）和磷（平均最大降幅12.28%）的最大降幅出现在30分钟时。甲状旁腺激素水平在45分钟时从基础值1.2 mg/ml±0.22显著升至2.1 ng/ml±0.32，而降钙素在15分钟时从基础水平90 pg/ml±14迅速升至127 pg/ml。总之，因摄入或输注葡萄糖或注射胰高血糖素导致的血糖和胰岛素升高，不仅与血清钙和磷的下降有关，还与甲状旁腺激素和降钙素的升高有关。
