Grisham J W
Ann N Y Acad Sci. 1980;349:128-37. doi: 10.1111/j.1749-6632.1980.tb29521.x.
Under the conditions of this experiment, propagable hepatic epithelial cells in long-term culture were derived from a small, nonparenchymal precursor cell present in the liver in vivo. Progeny of the nonparenchymal precursor cell weakly expressed some hepatocyte-like properties in culture. Hepatocytes were not clonogenic under the conditions of this experiment. Propagable hepatic epithelial cells in long-term culture probably originate from hepatic stem cells in vivo. Terminal biliary ductular cells are facultative stem cells for hepatocytes.
在本实验条件下，长期培养的可增殖肝上皮细胞源自体内肝脏中存在的一种小的非实质前体细胞。该非实质前体细胞的后代在培养中弱表达一些肝细胞样特性。在本实验条件下，肝细胞不具有克隆形成能力。长期培养的可增殖肝上皮细胞可能起源于体内的肝干细胞。终末胆小管细胞是肝细胞的兼性干细胞。
