Hamed A T, Lokhandwala M F, Jandhyala B S
Arch Int Pharmacodyn Ther. 1981 Feb;249(2):264-74.
Factors regulating hindlimb vascular resistance were comparatively evaluated in groups of mongel dogs anesthetized either with sodium pentobarbital(p) or morphine + chloralose (M + C). Pressure flow curved obtained in the perfused hindlimb studies indicated that, while the overall hindlimb resistance is greater in M + C group, the resting neurogenic tone and the tone contributed by circulating catecholamines were essentially similar in both groups. Thus the data suggest that myogenic activity is greater under M + C anesthesia, and this phenomenon may be related to differences in the plasma renin activity noted in the two groups. Vasodilator responses to isoproterenol and acetylcholine were not different between the groups while the vasoconstrictor responses to norepinephrine were greater in M + C group. It is suggested that the differences noted in the vascular profile of dogs under these two anesthetics may have some influence on the pharmacological effect of agents studied.
对分别用戊巴比妥钠（p）或吗啡+氯醛糖（M+C）麻醉的几组杂种犬后肢血管阻力的调节因素进行了比较评估。在灌注后肢研究中获得的压力-流量曲线表明，虽然M+C组的整体后肢阻力更大，但两组的静息神经源性张力和循环儿茶酚胺所致的张力基本相似。因此，数据表明在M+C麻醉下肌源性活动更强，这种现象可能与两组中观察到的血浆肾素活性差异有关。两组对异丙肾上腺素和乙酰胆碱的血管舒张反应无差异，而M+C组对去甲肾上腺素的血管收缩反应更强。提示在这两种麻醉剂作用下犬的血管特征差异可能对所研究药物的药理作用有一定影响。
