Dutreix J, Dutreix A, Naudy S
Bull Cancer. 1981;68(1):63-70.
The aims of total body irradiation, namely immunologic suppression of the hematopoietic tissues and eventually eradication of leukemia, require a large dose which may cause detrimental effects on healthy tissues. The main problem is raised by the interstitial pneumonitis and a relative protection of the lung is advisable. A partial reduction of the dose to the lung may cause an important increase of the number of surviving cells in the cell population the irradiation is aiming aiming at. Technical problems are raised to keep this increase to an acceptable value. A relative protection of the critical tissues can be achieved by a convenient time distribution of the dose, since the repair of sublethal injuries taking place between the sessions of a fractionated irradiation or during the course of low dose rate irradiation is larger for intestine, lung..., than for bone marrow and probably leukemic cells. Animal experiments have provided radiobiological data for estimating the therapeutic benefit related to the fraction number or to the dose rate.
全身照射的目的，即对造血组织进行免疫抑制并最终根除白血病，需要大剂量照射，而这可能会对健康组织产生有害影响。主要问题是间质性肺炎，因此对肺部进行相对保护是可取的。肺部剂量的部分降低可能会导致照射目标细胞群体中存活细胞数量显著增加。要将这种增加控制在可接受的值会引发技术问题。通过合理的剂量时间分布可以实现对关键组织的相对保护，因为在分次照射的各次照射之间或低剂量率照射过程中发生的亚致死损伤修复，在肠道、肺部……比在骨髓以及可能的白血病细胞中更大。动物实验提供了放射生物学数据，用于评估与分次次数或剂量率相关的治疗益处。
