Shimojo N, Funae Y, Fujii S, Wada M
Clin Chim Acta. 1981 Feb 5;109(3):345-9. doi: 10.1016/0009-8981(81)90321-1.
The molecular weight of plasma renin from healthy subjects and patients with nephrotic syndrome, in whom we previously reported that plasma inactive renin was increased, was studied by gel filtration. Activation was performed by acid treatment. The plasma from healthy subjects contains a low molecular weight from of renin (40 000) and a high molecular weight form which can be separated into two peaks of 52 000 and 60 000. After acid activation, renin activity was increased in the high molecular form but not significantly in the low molecular form. Although the increase of renin activity in the high molecular weight form after acid activation was larger in patients with nephrotic syndrome, the gel filtration profile was similar to that of healthy subjects.
通过凝胶过滤研究了健康受试者和肾病综合征患者血浆肾素的分子量，我们之前报道过这些肾病综合征患者血浆中的无活性肾素增加。通过酸处理进行激活。健康受试者的血浆含有低分子量形式的肾素（40000）和高分子量形式的肾素，后者可分离为52000和60000的两个峰。酸激活后，高分子量形式的肾素活性增加，而低分子量形式的肾素活性增加不显著。虽然肾病综合征患者酸激活后高分子量形式的肾素活性增加幅度更大，但其凝胶过滤图谱与健康受试者相似。
