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Xipamide: no advantage over bendrofluazide in hypertension.

作者信息

Ramsay L E, Freestone S

出版信息

Br J Clin Pharmacol. 1984 Oct;18(4):616-8. doi: 10.1111/j.1365-2125.1984.tb02514.x.

Abstract

In patients with uncontrolled hypertension addition of xipamide 20 mg daily to bendrofluazide 5 mg daily produced no significant additive antihypertensive effect, and the 95% confidence limits excluded a clinically important response. Xipamide treatment worsened hypokalaemia and increased the blood urea concentration significantly.

摘要

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本文引用的文献

1
A study of the antihypertensive action of xipamide using ambulatory intra-arterial monitoring.
Br J Clin Pharmacol. 1981 Sep;12(3):381-5. doi: 10.1111/j.1365-2125.1981.tb01230.x.
2
Sample size for short-term trials of antihypertensive drugs.
Br J Clin Pharmacol. 1982 Aug;14(2):265-8. doi: 10.1111/j.1365-2125.1982.tb01971.x.
3
Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium.
Br J Clin Pharmacol. 1982 Jun;13(6):859-63. doi: 10.1111/j.1365-2125.1982.tb01879.x.
7
Evaluation of beta blockade bendrofluazide, and prazosin in severe hypertension.
Lancet. 1977 Feb 5;1(8006):271-4. doi: 10.1016/s0140-6736(77)91822-0.

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