氯噻嗪：在治疗高血压方面并不比苄氟噻嗪更具优势。
Xipamide: no advantage over bendrofluazide in hypertension.
作者信息
Ramsay L E, Freestone S
出版信息
Br J Clin Pharmacol. 1984 Oct;18(4):616-8. doi: 10.1111/j.1365-2125.1984.tb02514.x.
Abstract
In patients with uncontrolled hypertension addition of xipamide 20 mg daily to bendrofluazide 5 mg daily produced no significant additive antihypertensive effect, and the 95% confidence limits excluded a clinically important response. Xipamide treatment worsened hypokalaemia and increased the blood urea concentration significantly.
摘要
在未控制高血压的患者中，每日在5毫克苄氟噻嗪基础上加用20毫克希帕胺，未产生显著的附加降压效果，且95%置信区间排除了具有临床意义的反应。希帕胺治疗使低钾血症恶化，并显著提高了血尿素浓度。
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本文引用的文献
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Br J Clin Pharmacol. 1981 Sep;12(3):381-5. doi: 10.1111/j.1365-2125.1981.tb01230.x.
2
Sample size for short-term trials of antihypertensive drugs.抗高血压药物短期试验的样本量。
Br J Clin Pharmacol. 1982 Aug;14(2):265-8. doi: 10.1111/j.1365-2125.1982.tb01971.x.
3
Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium.氯磺水杨胺和环戊噻嗪治疗原发性高血压——对血压和血钾的比较效果
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