Ramsay L E, Freestone S
Br J Clin Pharmacol. 1984 Oct;18(4):616-8. doi: 10.1111/j.1365-2125.1984.tb02514.x.
In patients with uncontrolled hypertension addition of xipamide 20 mg daily to bendrofluazide 5 mg daily produced no significant additive antihypertensive effect, and the 95% confidence limits excluded a clinically important response. Xipamide treatment worsened hypokalaemia and increased the blood urea concentration significantly.