Warkany J, O'Toole B A
Childs Brain. 1981;8(1):18-30. doi: 10.1159/000119965.
Seven litters and 17 near-term rats of mothers treated with teratogens during gestation were analyzed for concordance and discordance of congenital malformations of the central nervous system. In animals with spina bifida a firm association with Arnold-Chiari malformation was found but only in fetuses near term. Associations with aqueduct stenosis and hydrocephalus were poor. In general, the findings support the theory that the components of the spina bifida complex develop from a common teratogenic disturbance but independent from each other.
对孕期接受致畸剂处理的7窝及17只近足月大鼠进行分析，以研究中枢神经系统先天性畸形的一致性和不一致性。在患有脊柱裂的动物中，发现与阿诺德-奇阿利畸形有密切关联，但仅在近足月胎儿中存在。与导水管狭窄和脑积水的关联较弱。总体而言，这些发现支持以下理论：脊柱裂复合体的各个组成部分由共同的致畸干扰发育而来，但彼此独立。
