Docherty T B, Herbaut A G, Sedgwick E M
Wessex Neurological Centre, Southampton, UK.
J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1318-22. doi: 10.1136/jnnp.50.10.1318.
Brainstem auditory evoked potentials and clinical findings were examined in 18 children over the age of 5 years who were born with myelomeningocoele which was closed at birth, and whose hydrocephalus was managed by long term shunting in most of them. The potentials were compared with age and sex matched normal subjects and with four patients with hydrocephalus only. All but one had an abnormal brainstem auditory evoked potential with 72% showing a delay in the II-V and I-V interpeak latencies of more than three standard deviations. It is proposed that the abnormalities are a reflection of brainstem dysgenesis which is part of an associated Arnold-Chiari malformation, though the malformation was clinically asymptomatic in all. The usefulness of the brainstem auditory evoked potential for assessing the course of hydrocephalus and for predicting symptomatic Arnold-Chiari malformation is questioned.
对18名5岁以上的儿童进行了脑干听觉诱发电位和临床检查。这些儿童出生时患有脊髓脊膜膨出，出生时已闭合，大多数患儿的脑积水通过长期分流治疗。将这些电位与年龄和性别匹配的正常受试者以及4名仅患有脑积水的患者进行了比较。除1人外，所有人的脑干听觉诱发电位均异常，72%的患者II-V和I-V峰间期潜伏期延迟超过三个标准差。有人提出，这些异常反映了脑干发育不全，这是相关Arnold-Chiari畸形的一部分，尽管在所有患者中该畸形在临床上均无症状。有人质疑脑干听觉诱发电位在评估脑积水病程和预测症状性Arnold-Chiari畸形方面的实用性。
