Kok-van Alphen C C, Völker-Dieben H J, van der Want J J, Vrensen G
Doc Ophthalmol. 1981 Mar 20;50(2):275-82. doi: 10.1007/BF00158009.
As introduction to a light- and electron-microscopial examination of rejected human corneal grafts a summary is given of the clinical signs of rejection. It is extremely important to recognize these signs in time and to initiate the correct therapy. Most failures in corneal transplantation are due to rejection. Rejection reactions are often not recognized early enough. The differential diagnosis is difficult because so many factors can trigger off a rejection. As the diagnosis is so often missed it is a good thing to consider the clinical picture of graft rejection once more. Maumenee: 'most ophthalmologists do not recognize the signs of early graft failure and usually do not refer the patient back for therapy until considerable oedema has developed from endothelial destruction' (1962). In the cases with a good prognosis the rejection percentage is plus or minus 12%; in vascularized corneas and complicated corneal transplantations as high as 75% (Polack, 1977).
作为对人角膜移植排斥反应的光学显微镜和电子显微镜检查的引言，现将排斥反应的临床体征进行总结。及时识别这些体征并启动正确的治疗极为重要。角膜移植失败大多是由排斥反应所致。排斥反应常常未能得到足够早的识别。鉴别诊断很困难，因为诸多因素都可能引发排斥反应。鉴于诊断常常被漏诊，再次审视移植排斥反应的临床表现是有好处的。莫梅尼：“大多数眼科医生未识别出早期移植失败的体征，通常直到内皮细胞破坏导致相当程度的水肿出现时才将患者转回进行治疗”（1962年）。预后良好的病例中，排斥率约为±12%；在角膜血管化和复杂角膜移植病例中，排斥率高达75%（波拉克，1977年）。
