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是否存在对能量利用效率的交感神经调节?

Is there a sympathetic regulation of the efficiency of energy utilization?

作者信息

Girardier L, Seydoux J

出版信息

Diabetologia. 1981 Mar;20 Suppl:362-5.

PMID:7014332
Abstract

Brown adipose tissue, a well known effector of regulatory thermogenesis found in mammals, is unique in its ability to steadily increase its heat production several fold for very long periods of time. It constitutes a shunt of energy flow between food intake and heat dissipation, it is activated through its sympathetic nerve supply. There are evidence in the rat, that brown adipose tissue is activated following overfeeding, thus decreasing food efficiency and determining resistance to obesity. Genetically obese (ob/ob) mice fed and kept at 22 degrees C lack the possibility of activating their brown fat energy shunt; they are known to be poorly resistant to cold stress despite their large insulation. This is taken as a further circumstantial evidence of an overlap in thermal and food efficiency regulatory systems in rodents through sympathetically controlled brown fast as a common effector.

摘要

棕色脂肪组织是哺乳动物体内一种著名的调节性产热效应器,其独特之处在于能够在很长一段时间内持续将产热提高数倍。它构成了食物摄入与散热之间能量流动的旁路,通过交感神经供应被激活。在大鼠中有证据表明,过度喂养后棕色脂肪组织会被激活,从而降低食物效率并决定对肥胖的抵抗力。在22摄氏度下饲养的遗传性肥胖(ob/ob)小鼠没有激活其棕色脂肪能量旁路的可能性;尽管它们有厚厚的脂肪层,但已知它们对冷应激的抵抗力很差。这被视为通过交感神经控制的棕色脂肪作为共同效应器,啮齿动物的热调节和食物效率调节系统存在重叠的又一间接证据。

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