Nicolaidis S
Diabetologia. 1981 Mar;20 Suppl:426-34.
States of hunger and satiety are under ischymetric (i.e., rate of cellular energy production) control which depends on both substrate availability and hormonal composition. The latter varies in response to external (olfactory, gustatory and gastrointestinal) stimuli sensed by specific receptors and projected on lateral hypothalamic (LH) units from which departs the descendant control pathway of metabolic glands. This neurohormonal loop is responsible for the anticipatory glycemic and other changes observed during a meal and the preabsorptive "satiation" ending the meal long before the postabsorptive cellular repletion will induce the state of more permanent "satiety". New data on LH "sweet" taste projection and hypothalamo-pancreatic control are shown and strengthen the above view.
饥饿和饱腹感状态受等容性（即细胞能量产生速率）控制，这取决于底物可用性和激素组成。后者会根据特定受体感知到的外部（嗅觉、味觉和胃肠道）刺激而变化，并投射到下丘脑外侧（LH）单元，代谢腺体的下行控制途径由此出发。这个神经激素回路负责进食期间观察到的预期血糖变化和其他变化，以及在吸收后细胞充实诱导更持久的“饱腹感”状态之前很久就结束进食的吸收前“饱腹感”。展示了关于LH“甜味”投射和下丘脑 - 胰腺控制的新数据，并强化了上述观点。
