Tanaka F, Sawada K, Yonemoto R H
Gan. 1980 Oct;71(5):589-95.
The correlation of serum capacity for blocking and arming with effector cell reactivity has been examined in patients with breast cancer by using the leukocyte adherence inhibition (LAI) assay. It was found that sera from breast cancer patients possessed the ability to make nonimmune mononuclear cells specifically reactive (i.e., armed) to the breast cancer extract and to specifically block the reactivity of mononuclear cells from breast cancer patients with the cancer extract. Sera from patients with breast cancer whose mononuclear cells were nonreactive to the corresponding tumor extract (6/8) showed higher blocking than sera from patients whose cells showed reactivity to the corresponding tumor extract (3/13). Similarly, sera from patients with positive LAI response (6/13) induced arming of normal mononuclear cells more often than sera from patients with negative LAI (2/8). There also appeared to be an inverse correlation between the capacities of serum from breast cancer patients to exhibit blocking and arming. That is, serum arming activity was found only in sera which showed no blocking, and serum blocking activity was detected only in sera without arming, activity, except for one sample. The possibility is discussed that immune complexes play a key role in both serum activities, and that their biphasic character might be dependent on the ratio of antigen of antibody.
通过白细胞黏附抑制（LAI）试验，对乳腺癌患者血清的封闭和武装能力与效应细胞反应性之间的相关性进行了研究。发现乳腺癌患者的血清具有使非免疫性单核细胞对乳腺癌提取物产生特异性反应（即武装）以及特异性阻断乳腺癌患者单核细胞与癌提取物反应性的能力。其单核细胞对相应肿瘤提取物无反应的乳腺癌患者（6/8）的血清，比其细胞对相应肿瘤提取物有反应的患者（3/13）的血清表现出更高的封闭能力。同样，LAI反应阳性的患者（6/13）的血清比LAI阴性的患者（2/8）的血清更常诱导正常单核细胞的武装。乳腺癌患者血清的封闭和武装能力之间似乎也存在负相关。也就是说，仅在无封闭作用的血清中发现血清武装活性，而仅在无武装活性的血清中检测到血清封闭活性，但有一个样本除外。文中讨论了免疫复合物在这两种血清活性中起关键作用的可能性，以及它们的双相特性可能取决于抗原与抗体的比例。
