Wangsness P J, Martin R J, Gatchel B B
Growth. 1980 Dec;44(4):318-26.
The effect of intravenous (IV) infusion of insulin on subsequent serum growth hormone (GH) response was studied in fasted lean, fast-growing and in genetically obese, slow-growing pigs at 6 months of age. A smaller GH response in obese compared to lean pigs was observed from 30 to 60 min after insulin infusion. Concurrently, marked hypoglycemia and a decrease in serum free fatty acids (FFA) were evident. Changes in serum glucose and FFA were similar in both pig strains. After IV administration of exogenous GH, the decrease in serum GH (half-life) and the simultaneous increase in serum FFA were not different for lean and obese pigs. The reduced GH secretory potential in obese pigs is consistent with reduced muscle development and growth rate.
研究了静脉输注胰岛素对6月龄空腹的瘦型、快速生长型以及遗传性肥胖、生长缓慢型猪随后血清生长激素（GH）反应的影响。在输注胰岛素后30至60分钟观察到，肥胖猪的GH反应比瘦猪小。同时，明显出现低血糖和血清游离脂肪酸（FFA）减少。两种猪品系的血清葡萄糖和FFA变化相似。静脉注射外源性GH后，瘦猪和肥胖猪血清GH的降低（半衰期）以及血清FFA的同时增加并无差异。肥胖猪GH分泌潜力降低与肌肉发育和生长速率降低一致。
