Wangsness P J, Martin R J, Gahagan J H
Am J Physiol. 1977 Aug;233(2):E104-8. doi: 10.1152/ajpendo.1977.233.2.E104.
Plasma glucose, immunoreactive insulin (IRI), and growth hormone (GH) were determined in fasted lean and genetically obese pigs at 1, 3, and 6 mo of age. Rate of glucose clearance and plasma IRI and GH response in provocative stimulation were also measured. Fasting glucose was similar in lean and obese pigs, whereas glucose clearance rate was more rapid in lean pigs. Obese pigs were not hyperinsulinemic but had lower plasma GH than lean pigs. At 1 mo of age, both lean and obese pigs had higher plasma IRI and GH as compared to 3 and 6 mo. Glucose infusion produced increases in plasma IRI at 1, 3, and 6 mo, respectively, with the greatest increases at 6 mo. Plasma IRI peaked at the same level in both pig types at a given age; but due to a more prolonged response in obese pigs, the overall IRI response to glucose infusion was greater in obese pigs. Arginine infusion caused much smaller IRI responses than glucose, but the response of obese pigs was significantly greater than that of lean pigs. Both provocative stimuli caused increases in plasma GH. The GH response to glucose infusion in obese pigs was considerably less than in lean pigs. These observations suggest mild insulin insensitivity and a reduced GH secretory potential in the obese as compared to lean pigs.
在1、3和6月龄的空腹瘦猪和遗传性肥胖猪中测定了血浆葡萄糖、免疫反应性胰岛素（IRI）和生长激素（GH）。还测量了葡萄糖清除率以及刺激激发时血浆IRI和GH的反应。瘦猪和肥胖猪的空腹血糖相似，但瘦猪的葡萄糖清除率更快。肥胖猪并非高胰岛素血症，但血浆GH水平低于瘦猪。1月龄时，瘦猪和肥胖猪的血浆IRI和GH均高于3月龄和6月龄时。葡萄糖输注分别在1、3和6月龄时使血浆IRI升高，6月龄时升高幅度最大。在给定年龄，两种猪的血浆IRI峰值水平相同；但由于肥胖猪的反应持续时间更长，肥胖猪对葡萄糖输注的总体IRI反应更大。精氨酸输注引起的IRI反应比葡萄糖小得多，但肥胖猪的反应明显大于瘦猪。两种刺激激发均导致血浆GH升高。肥胖猪对葡萄糖输注的GH反应明显低于瘦猪。这些观察结果表明，与瘦猪相比，肥胖猪存在轻度胰岛素不敏感且GH分泌潜力降低。
