Kühl C, Hornnes P J, Faber O K
Horm Metab Res. 1981 Feb;13(2):71-2. doi: 10.1055/s-2007-1019176.
The hepatic degradation of insulin in late pregnancy has been estimated by determination of the molar C-peptide: Insulin (C/l) ratio under fasting conditions in 20 normal women in late pregnancy and again 4--8 weeks post-partum. Fasting plasma C-peptide and insulin concentrations were both significantly enhanced in pregnancy. However, since the relative gestational increments in plasma C-peptide and insulin concentrations were of almost the same magnitude, the C/l ratio remained unaffected by pregnancy (7.3 +/- 0.07 (mean +/- S.E.M) (pregnancy) vs. 7.4 +/- 0.8 (post-partum), N.S.). The results suggest that, in pregnancy, peripheral hyperinsulinaemia is due, in general, to pancreatic hypersecretion rather than to diminished hepatic extraction of insulin.
通过测定20名正常妊娠晚期妇女空腹状态下的摩尔C肽：胰岛素（C/I）比值，评估了妊娠晚期胰岛素的肝脏降解情况，并在产后4 - 8周再次进行测定。妊娠期间空腹血浆C肽和胰岛素浓度均显著升高。然而，由于血浆C肽和胰岛素浓度的相对妊娠增量几乎相同，C/I比值不受妊娠影响（妊娠时为7.3±0.07（均值±标准误），产后为7.4±0.8，无显著性差异）。结果表明，在妊娠期间，外周高胰岛素血症一般是由于胰腺分泌过多，而非肝脏对胰岛素的摄取减少所致。
