Hornnes P J, Kuhl C
Obstet Gynecol. 1980 Apr;55(4):425-7.
In order to investigate the responses of insulin and glucagon to the same glycemic stimulus in late normal pregnancy and post partum, appropriate quantities of glucose were infused intravenously in 7 normal women at both stages. In this manner similar glucose curves were obtained in the 2 conditions. The insulin response to glucose infusion was increased 3.8 times in late pregnancy, whereas the suppression of glucagon was similar in late pregnancy and post partum. The results confirm that the beta-cell sensitivity to a glycemic stimulus is substantially increased in normal late pregnancy, but the alpha-cell sensitivity to a glycemic stimulus is unaffected by pregnancy.
为了研究正常妊娠晚期及产后胰岛素和胰高血糖素对同一血糖刺激的反应，对7名处于这两个阶段的正常女性静脉输注适量葡萄糖。通过这种方式，在两种情况下获得了相似的血糖曲线。妊娠晚期对葡萄糖输注的胰岛素反应增加了3.8倍，而妊娠晚期和产后对胰高血糖素的抑制作用相似。结果证实，正常妊娠晚期β细胞对血糖刺激的敏感性显著增加，但α细胞对血糖刺激的敏感性不受妊娠影响。
