Zipf W B, O'Dorisio T M, Cataland S, Sotos J
J Clin Endocrinol Metab. 1981 Jun;52(6):1264-6. doi: 10.1210/jcem-52-6-1264.
Serum pancreatic polypeptide (PP), gastric inhibitory polypeptide (GIP), insulin and glucose responses to meal stimulation were studied in 10 normal weight patients, 13 normal obese patients and 7 patients with Prader-Willi syndrome (PWS) associated obesity. Serum and plasma concentrations of PP, glucose, insulin and GIP were obtained at 15 min intervals from 0-180 min. after a 275 K calorie meal. Basal and peak responses of glucose, for patients with PWS were significantly lower when compared to normal or obese controls. Basal and peak insulin responses in PWS were significantly greater than those of the normal controls but still less than those of the obese controls. Basal GIP concentrations in the patients with PWS were significantly less than normals and their peak response was less than the obese control group. No significant differences in basal or peak PP responses were noted between normal and obese controls. All 7 patients with PWS had abnormal PP responses. Five failed to show significant PP release after the stimulation; one had a peak response to 130 pg/ml while the 7th patient (PB) had an exaggerated response to 2000 pg/ml. The 6 patients with low or no response had basal PP values of 62 +/- 12 pg/ml and a mean PP peak response of 78 +/- 15 pg/ml. This observation of blunted PP response in a human model of hyperphagia and obesity parallels the animal models and suggests PP may have a significant role in appetite control.
在10名体重正常的患者、13名正常肥胖患者和7名患有普拉德-威利综合征（PWS）相关肥胖症的患者中，研究了血清胰多肽（PP）、胃抑制多肽（GIP）、胰岛素和葡萄糖对进餐刺激的反应。在摄入一顿275千卡热量的餐后，每隔15分钟采集0至180分钟的血清和血浆中PP、葡萄糖、胰岛素和GIP的浓度。与正常或肥胖对照组相比，PWS患者的葡萄糖基础反应和峰值反应显著降低。PWS患者的胰岛素基础反应和峰值反应显著高于正常对照组，但仍低于肥胖对照组。PWS患者的基础GIP浓度显著低于正常人，其峰值反应低于肥胖对照组。正常对照组和肥胖对照组之间的基础或峰值PP反应无显著差异。所有7名PWS患者的PP反应均异常。5名患者在刺激后未显示出显著的PP释放；1名患者的峰值反应为130 pg/ml，而第7名患者（PB）对2000 pg/ml有过度反应。6名反应低下或无反应的患者的基础PP值为62±12 pg/ml，平均PP峰值反应为78±15 pg/ml。在人类贪食和肥胖模型中观察到的PP反应迟钝与动物模型相似，提示PP可能在食欲控制中起重要作用。
