Fry F J, Goss S A, Patrick J T
J Neurosurg. 1981 May;54(5):659-63. doi: 10.3171/jns.1981.54.5.0659.
Focused ultrasound has been used for focal modifications of brain tissue and in preliminary studies of the application of ultrasonic techniques for tissue modification in human stereotaxic neurosurgery; however, the technique has been seriously compromised by the necessity of removal of intervening skull. Such removal was necessary to avoid distortion and extremely large attenuation of the ultrasonic beam which resulted from passage through bone. Recent studies have shown that under proper conditions focal beams of ultrasound can be transmitted with tolerable and attenuation through skull, suggesting the possibility of transkull lesion production in brain. This report describes the acoustical parameters and histological features of focal brain lesions produced in 10 craniectomized cats with intense focal ultrasonic beams which first had passed through a formalin-fixed human skull overlay. The histological appearance of these lesions produced to date is similar to that produced previously without intervening skull.
聚焦超声已被用于脑组织的局部改变，以及在人类立体定向神经外科中超声技术用于组织改变的初步研究；然而，由于需要去除中间的颅骨，该技术受到了严重影响。这种去除是必要的，以避免超声束穿过骨骼时产生的畸变和极大的衰减。最近的研究表明，在适当的条件下，聚焦超声束可以通过颅骨以可耐受的衰减进行传输，这表明了经颅骨在脑内产生病变的可能性。本报告描述了在10只颅骨切除的猫中，通过先穿过福尔马林固定的人类颅骨覆盖物的强聚焦超声束产生的局灶性脑损伤的声学参数和组织学特征。迄今为止产生的这些损伤的组织学外观与之前在没有中间颅骨的情况下产生的损伤相似。
