维生素A缺乏时大鼠上皮组织的DNA标记

DNA labeling of rat epithelial tissues in vitamin A deficiency.

作者信息

Zile M H, Bunge E C, DeLuca H F

出版信息

J Nutr. 1981 May;111(5):777-88. doi: 10.1093/jn/111.5.777.

DOI:10.1093/jn/111.5.777

Abstract

We examined the effect of vitamin A nutritional status on cell division in various epithelial tissues of the rat. Tissues were examined by histological methods, and DNA labeling was assessed by autoradiography. Mild vitamin A deficiency decreased the DNA labeling index in the trachea and the epidermis, while not altering the histological appearance of the tissue. In some tracheae, foci of hyperplasia were present. The histological appearance and the DNA labeling index of the cornea, jejunum and colon were not altered by mild vitamin A deficiency. We concluded that a diminished proliferation of epithelial cells is a manifestation of suboptimal vitamin A availability in that tissue.

摘要

我们研究了维生素A营养状况对大鼠各种上皮组织细胞分裂的影响。通过组织学方法检查组织，并通过放射自显影评估DNA标记。轻度维生素A缺乏会降低气管和表皮中的DNA标记指数，而不会改变组织的组织学外观。在一些气管中，存在增生灶。轻度维生素A缺乏不会改变角膜、空肠和结肠的组织学外观和DNA标记指数。我们得出结论，上皮细胞增殖减少是该组织中维生素A供应不足的一种表现。