D-青霉胺对类风湿关节炎和原发性胆汁性肝硬化中循环蛋白复合物的影响。
Effects of D-penicillamine on circulating protein complexes in rheumatoid arthritis and primary biliary cirrhosis.
作者信息
Wollheim F A
出版信息
J Rheumatol Suppl. 1981 Jan-Feb;7:74-9.
PMID:7014877
Abstract
Not immunosuppressive in conventional test systems, D-penicillamine causes minor reductions in Ig levels and occasionally induces IgA deficiency. Rather limited evidence indicates actual decline in immune complexes; more data show reductions in levels of 9S IgG and alpha1-antitrypsin-IgA complexes. On the other hand, a number of instances of toxic reactions are most readily explained on the basis of autoimmunization. Changes in redox equilibrium, haptenization, and influence on T cell function are possible mechanisms.
摘要
在传统测试系统中，D-青霉胺无免疫抑制作用，它会使免疫球蛋白水平略有降低，偶尔会导致IgA缺乏。相当有限的证据表明免疫复合物实际减少；更多数据显示9S IgG和α1-抗胰蛋白酶-IgA复合物水平降低。另一方面，许多毒性反应实例最容易基于自身免疫来解释。氧化还原平衡的变化、半抗原化以及对T细胞功能的影响是可能的机制。
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