Holborow E J
Agents Actions Suppl. 1980;7:58-61.
In connective tissue diseases, putatively immunosuppressive drugs may lower antinuclear antibody (ANA), anti-DNA antibody and rheumatoid factor titres. Penicillamine may induce or increase titres of antinuclear and/or anti-muscle antibodies. The mechanism of induction of penicillamine antinuclear autoimmunity evidently differs from that seen with hydrallazine and procainamide. While the latter may induce circulating immune complex formation, the effect of penicillamine on circulating immune complex levels in rheumatoid arthritis is variable. Our recent findings will be discussed.
在结缔组织疾病中，假定具有免疫抑制作用的药物可能会降低抗核抗体（ANA）、抗DNA抗体和类风湿因子的滴度。青霉胺可能会诱导或增加抗核抗体和/或抗肌肉抗体的滴度。青霉胺诱导抗核自身免疫的机制显然与肼屈嗪和普鲁卡因胺不同。虽然后者可能会诱导循环免疫复合物的形成，但青霉胺对类风湿关节炎患者循环免疫复合物水平的影响是多变的。我们将讨论我们最近的研究发现。
